Stability of Reconstituted Telavancin Drug Product in Frozen Intravenous Bags
نویسندگان
چکیده
منابع مشابه
Chemical Stability of Telavancin in Elastomeric Pumps☆
BACKGROUND VIBATIV is a once-daily, injectable lipoglycopeptide antibiotic approved in the U.S. for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible isolates of Staphylococcus aureus when alternative treatments are not suitable. In addition, VIBATIV is approved in the U.S. for the treatment of adult patients with complicated skin...
متن کاملStability of Melphalan in 0.9 % Sodium Chloride Solutions Prepared in Polyvinyl Chloride Bags for Intravenous Injection
Melphalan is an alkylating agent frequently used in an intravenous formulation to treat hematologic malignancies and solid tumors in both adults and children. According to the manufacturer, melphalan is stable in sterile 0.9% sodium chloride for 90 min at room temperature (RT). Several authors have studied the stability of different concentrations of melphalan; however, most were not adapted to...
متن کاملPost-reconstitution Stability of Telavancin with Commonly Used Diluents and Intravenous Infusion Solutions
OBJECTIVE The post-reconstitution chemical stability and microbial challenge hold time of nonpreserved telavancin for injection was determined using common reconstitution diluents and intravenous (IV) infusion solutions stored at room temperature with light (ambient) or at 2°C to 8°C without light (refrigeration). METHODS Telavancin was reconstituted with 5% dextrose, 0.9% normal saline, or s...
متن کاملTissue penetration of telavancin after intravenous administration in healthy subjects.
The pharmacokinetic disposition of telavancin administered 7.5 mg/kg of body weight every 24 h was determined in plasma and skin blister fluid. The mean penetration of telavancin into blister fluid was 40%. This study reveals that adequate concentrations are achieved in both plasma and blister fluid for pathogens frequently implicated in skin and soft tissue infections.
متن کاملImpact of reconstituted cytosol on protein stability.
Protein stability is usually studied in simple buffered solutions, but most proteins function inside cells, where the heterogeneous and crowded environment presents a complex, nonideal system. Proteins are expected to behave differently under cellular crowding owing to two types of contacts: hard-core repulsions and weak, chemical interactions. The effect of hard-core repulsions is purely entro...
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2015
ISSN: 0018-5787,1945-1253
DOI: 10.1310/hpj5007-609